Probabilistic Modeling in Genomics Meeting

Visitor of the Week: Marjan Farahbod

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Meet Marjan Farahbod of Simon Fraser University (Canada). The postdoctoral fellow is a member of Dr. Maxwell Libbrecht’s lab where research focuses on gene annotation. Marjan joins us at this week’s Probabilistic Modeling in Genomics virtual meeting – her first meeting at CSHL.

Tell us about your research.  
I am working on obtaining a better understanding of gene regulatory mechanisms using epigenomics data. In particular, I am trying to understand gene regulatory mechanisms in lung function and COPD (Chronic Obstructive Pulmonary Disease).

How did you decide to focus on this area/project?
During my PhD, I worked on the inference of gene function and regulation from transcriptomic data. I am interested in gene regulatory mechanisms, data characterization and method development--this project has all these elements to various degrees. In recent years multiple epigenomics datasets have become available, making it possible to study gene regulation using this form of data. There is much work to do here and I am excited about it.

What and/or who is the inspiration behind your scientific journey?
My mentors and colleagues. Then there is the curiosity, the complexity and the never-ending thread of questions; along with the creativity and the ideas that lead to the answers!

What impact do you hope to make through your work?
I admire the collective effort of researchers to find answers and solve problems, and I see my work as a small contribution to this effort. I hope to share my skills and ideas, lead projects and inspire.

Where do you see yourself in five years?
As a relatively new postdoc, my contribution to the field has been mostly my research products in the form of publications. In the next five years, I hope to inspire and lead new research efforts.

What do you love most about being a researcher?
Perhaps being surrounded by the excitement of the unknown. The abundance of questions, and that there is always something interesting going on. Research can be intimidating too. Sometimes I find myself overwhelmed by how much I don't know at the beginning of a project, but once I start the actual research, the curiosity takes over. 

What drew you to attend this meeting?
The meeting was a great opportunity to hear from the experts in my field and learn about its recent advancements. Specifically, it was great to hear from Professor Anshul Kundaje on their work in motif syntax, this is relevant to my project and something that I will look into. 

What is your key takeaway from the Meeting; and how do you plan to apply it to your work?
At the end of her keynote talk, Professor Daphne Koller briefly talked about the key advancements in different fields through time, and where we are today in our field. Her description resonated with me and was inspiring.  We are in a unique era, where the technical advancements in high-throughput biology and machine learning allows us to ask questions that we were not able to ask 10 or even 5 years ago. To think what will be possible in the near future, and how many questions we will be able to answer is exciting. 

What feedback or advice would you share with someone considering to participate in this meeting?
Perhaps not specific to this meeting, but usually for me the keynote talks provide high-level views of the field and its challenges so I try to attend all of them, even if they are not directly related to my research. For the talks, I attend the sessions that are most relevant, and those are usually from the authors or labs that I know of or am familiar with their work. Posters are even more focused, and there is a chance to have in-depth conversations on specific approaches or datasets in the poster session.

What’s the most memorable thing that happened during the Meeting?
I think attending the meeting in its virtual form will be quite a memorable experience. I appreciate the efforts that went into the arrangement of such a setting. I particularly liked the pictures from the mission control posted on the Slack! It was also cool that everyone was just a Slack message away.

Image provided by Marjan Farahbod.

Thank you to Marjan for being this week's featured visitor. To meet other featured researchers - and discover the wide range of science that takes part in a CSHL meeting or course - go here.

Visitor of the Week: Anastasia Teterina

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Meet Anastasia Teterina of the University of Oregon. The Russian national is a postdoc in Patrick Phillips’ lab which is part of the Institute of Ecology and Evolution. Anastasia attended the Probabilistic Modeling in Genomics meeting (ProbGen) – her first meeting in CSHL – where she gave a talk on the impact of reproduction mode on polymorphism in roundworms entitled “Mode of reproduction drives the distribution of polymorphism across the genome: theory and empirical tests in Caenorhabditis nematodes”.

What are your research interests? What are you working on?
I’m interested in the population genomics of worms (nematodes), namely, how their mating system and recombination landscapes influence the genomic polymorphism patterns. Genotype-phenotype relationships and the ways to explore them is another personal research interest.

How did you decide to make this the focus of your research?
The study of natural variation can help to understand the biology and ecology of organisms and demonstrate how different factors – such as genomic organization, population demographics, and other aspects of population structure – change genetic diversity; an important theoretical problem that has various practical implementations.

How did your scientific journey begin?
When I was 5 years old, my grandfather, a nuclear physicist, told me that every tiny cell has information that encodes everything necessary to build an organism and maintain all its functions. Since then, I've been trying to understand how it works.

Was there something specific about Probabilistic Modeling in Genomics meeting that drew you to attend?
The announced meeting topics caught my attention as I am curious about the trends in this area and wanted to know more. The meeting was devoted to modeling methods in genetics and omics and approaches to explore specific parameters and their distributions. In my current project, I intensively apply evolutionary population simulation and a variety of bioinformatics methods, a majority of them implies the use of some models. And, last but not least, I wanted to meet and talk with those who developed the methods I use to discuss their application in specific projects.

What is your key takeaway from the meeting?
To find out the answer to your scientific problem, ask more questions, be curious and ask tricky ones; try different approaches and combine methods; and don’t forget to test with simulation how well you can explain the results.

What did you pick up or learn from the meeting that you plan to apply to your work?
At ProbGen, there were many talks on model development, genetic parameter estimation techniques, a lot of benchmarking of old/new approaches, very promising announcements of new algorithms, (of course) a ton of interesting research with detailed descriptions of the methods, and inspiring talks on the current state and future direction of the field. I’m going to recommend some of the algorithms to my labmates and apply several new-to-me methods on my datasets.

Additionally, the day before the ProbGen meeting, there was an amazing satellite meeting on population simulations, PopSim, during which we discussed the current issues in population genetics and ways to approach them.

If someone curious in attending a future iteration of this meeting asked you for feedback or advice on it, what would you tell him/her?
ProbGen is an excellent opportunity to meet with colleagues, discuss your project, and learn new methods.

What do you like most about your time at CSHL?
It was my first visit to the CSHL, and I really enjoyed the autumn colors and amazing nature. One morning, a few colleagues and I went to the Inner Harbor to watch the birds. Also, I liked the amusing sculptures scattered around the campus.

Thank you to Anastasia for being this week's featured visitor. To meet other featured scientists - and discover the wide range of science that takes part in a CSHL meeting or course - go here.